TrkB Works at Postsynaptic Sites
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چکیده
منابع مشابه
TrkB Works at Postsynaptic Sites
expression of homologous truncated TrkA had no effect on the pattern of receptor clusters. Furthermore, in mutant trkB ϩ/Ϫ mice in which the level of TrkB expression The classical view of neurotrophins as target-derived is reduced, small punctate AChR regions are also ob-survival factors in the developing nervous system has served. The morphological similarity of receptor clusters changed drama...
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Neurotrophins and tyrosine receptor kinase (Trk) receptors are expressed in skeletal muscle, but it is unclear what functional role Trk-mediated signaling plays during postnatal life. Full-length TrkB (trkB.FL) as well as truncated TrkB (trkB.t1) were found to be localized primarily to the postsynaptic acetylcholine receptor- (AChR-) rich membrane at neuromuscular junctions. In vivo, dominant-n...
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Tyrosine receptor kinase B (TrkB)-mediated signaling modulates synaptic structure and strength in hippocampal and other neurons, but the underlying mechanisms are poorly understood. Full-length and truncated TrkB are diffusely distributed throughout the dendrites and soma of rat hippocampal neurons grown in vitro. Manipulation of TrkB-mediated signaling resulted in dramatic changes in the numbe...
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ژورنال
عنوان ژورنال: Neuron
سال: 1999
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(00)81100-9